It Takes Two is an action-adventure video game with elements from platform games. It is specifically designed for split-screen cooperative multiplayer, which means that it must be played with another player through either local or online play. The game features a large number of game mechanics from various video game genres.
These gameplay mechanics are connected to the story and the theme of the level. For instance, in one level, Cody gains the ability to rewind time, whereas May can replicate herself. Players have to cooperate with each other and utilize these abilities in order to progress. The game also features a large number of minigames.